Limiting any essential amino acid initiates this signaling cascade, which leads to increased translation of a
“master regulator,” activating transcription factor (ATF) 4, and ultimately, to regulation of many steps
along the pathway of DNA to RNA to protein…
Link to Source:
Annual Review of Nutrition
NUTRITIONAL CONTROL OF GENE EXPRESSION: How Mammalian Cells Respond to Amino Acid Limitation*
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