Decreased rates of protein synthesis which occurred in rat livers perfused with amino acid-deficient medium were accompanied by a loss of polysomes and a doubling of concentrations of ribosomal subunits and monomers as compared to unperfused liver or livers perfused with amino acid-supplemented medium.

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The Journal of Biological Chemistry

The role of amino acids in the regulation of protein synthesis in perfused rat liver. I. Reduction in rates of synthesis resulting from amino acid deprivation and recovery during flow-through perfusion

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